Peter Crouch and David Bentley scored at White Hart Lane to keep Spurs in fourth place with 41 points, above a clutch of teams battling for a shot at next season's Champions League.
Liverpool, runners-up to Manchester United last season, could not break down Wolves despite Steven Gerrard returning from a hamstring injury to play the full 90 minutes but moved up one place to fifth, three points back.
A terrible lapse in Fulham's defence gifted Spurs their opener after 28 minutes, Crouch scoring from close range after Luca Modric robbed a day-dreaming Bjorn Helge Riise in the area and crossed low for the England striker to convert.
Riise was involved in Tottenham's second goal early in the second half, although this time he was unlucky as Bentley's curling free kick flicked off his head to wrong foot Fulham goalkeeper Mark Schwarzer.
"Three points was the main thing tonight," Tottenham manager Harry Redknapp, whose side have stuttered of late, told Sky Sports. "It was a good performance and well deserved, we dominated the game and our keeper didn't have much to do."
"We had another 11 players on the pitch who did well," Benitez told the BBC. "Today we had to decide between Gerrard and Aquilani and we thought Gerrard would be more dangerous going forward. The positive was Gerrard playing 90 minutes."
Chung Yong Lee's goal was enough for Bolton to beat rivals Burnley at the Reebok Stadium where some away fans held aloft "Judas" banners aimed at Coyle.
