After narrowly missing out on qualification for the Champions League last season, Villas-Boas' men will take their place in Europe's second-tier club competition - and they begin their campaign with a 2,000-mile trip to Georgia for the first leg of their play-off tie.
Tottenham have a rich history in Europe, having won the inaugural edition of what was then known as the UEFA Cup back in 1972 before going on to taste success again in 1984.
Dinamo's finest hour in European competition arguably came in 1981, when they lifted the Cup Winners' Cup for the first and only time in their history.
Ahead of this year's meeting, they have few injury worries - although they remain without the services of winger Gareth Bale.
Tottenham have enjoyed a productive transfer window, and they will be able to call on new signings Nacer Chadli and Roberto Soldado in attack in Bale's absence.
For Georgian Premier League champions Dinamo, meanwhile, their biggest threat comes in the form of Spanish striker Xisco, who netted 22 goals to finish as the Georgian top flight's leading scorer last term.
