The teams shared a goalless draw in Belgrade on matchday one in Group E, but it has been a story of contrasting fortunes thereafter.
Back-to-back victories over Asteras Tripolis, thanks largely to England Under-21 striker Harry Kane taking his group goal tally to an impressive five, have placed Tottenham firmly in the driving seat.
Sasa Markovic belatedly scored his club's solitary goal of the round robin phase 13 minutes from time at Besiktas last time out, by which point Marko Nikolic's men were on their way to a third consecutive defeat.
Pochettino must also run the rule over a host of players listed as doubtful, including attacking midfielder Nacer Chadli (knee), Andros Townsend (ankle) and forwards Emmanuel Adebayor (back) and Roberto Soldado (knock).
Nevertheless, the Argentinian has been happy to give opportunities to his squad players throughout the European campaign - something that paid obvious dividends with Kane’s emergence, with the forward now a regular face domestically.
Left-back Ben Davies added a maiden Premier League start to six in the Europa League when Tottenham secured a dramatic 2-1 Premier League win over Hull City on Sunday and the close-season addition from Swansea City hopes to follow a similar path to that trodden by Kane.
"It's important for me," he told Tottenham's official website.
"I've waited a while and I'm delighted to have got there. Hopefully it's the first of many. I want to kick on from here."
