Dutchman Van Persie, who struck a hat-trick in the 3-2 win against Southampton in United's last game, suffered a strain on international duty but manager Sir Alex Ferguson said he had recovered in time for the visit of Wigan.
"On the injury front, everyone's fit, apart from the ones we know about - Jones and [Chris] Smalling," Ferguson said at his pre-match news conference.
"Jones was a bad blow for us. He got an injury in training last weekend and he'll be out for eight to 10 weeks."
Wayne Rooney is still out with a cut leg.
Manchester City manager Roberto Mancini said Sergio Aguero could play against Stoke City on Saturday after being sidelined since the opening day of the season with a knee injury.
The Argentina striker was feared to have sustained a serious injury but Mancicni said his recovery had gone well.
"We will try this morning with Sergio," Mancini said on Friday. "And after we try we will decide. He is getting better."
Italian Mario Balotelli is also available after recovering from an eye problem.
Former England, Liverpool and Manchester United striker Michael Owen could make his Stoke City debut against Manchester City on Saturday.
Owen, a free agent who joined after the transfer window closed, could even link up again with another of England's discarded strikers in the form of Peter Crouch.
"There's no doubt that I've played with Peter a number of times and we've done pretty well together, that's there for all to see," Owen said this week.
"It would be pretty disrespectful, though, for me to come in and say 'I'm looking forward to playing with Peter Crouch'. There are a lot of good players here, and it's certainly not in my contract that I'll be starting every game."
Early leaders Chelsea, who will be protecting a 100 percent start against local neighbours Queens Park Rangers on Saturday, will have John Terry and Ashley Cole available, manager Roberto Di Matteo said.
Terry injured his ankle playing for England in Moldova and missed Tuesday's draw with Ukraine, while Cole missed both England games.
It is the first meeting between the sides since Terry was cleared of racially abusing QPR's Anton Ferdinand in July and the clubs are still discussing whether the pre-match handshake formalities will go ahead as normal after they were abandoned in the previous two meetings between the clubs.
Arsenal may not risk midfielder Abou Diaby against Southampton on Saturday as manager Arsene Wenger looks ahead to a busy week ahead with a Champions League opener and an away trip to Premier League champions Manchester City.
"He is 50/50 at the moment," Wenger told Arsenal's website. "It is a small muscular problem that is very minor. But of course we are in a situation that, because we play so many games now, should we take a gamble with him or not?"
"We are playing on Saturday, Tuesday, then go to Man City."
Theo W
‘After Manchester City’s recent form, maybe they’re the underdogs against Manchester United!’ Former Red Devils defender on this weekend’s derby
‘Arteta, Alonso, Emery, me… none of us were physical players – we needed the understanding of the game. That probably helped us move into management’: Premier League boss reveals reasons for natural career progression
