Dutchman Van Persie, who struck a hat-trick in the 3-2 win against Southampton in United's last game, suffered a strain on international duty but manager Sir Alex Ferguson said he had recovered in time for the visit of Wigan.
"On the injury front, everyone's fit, apart from the ones we know about - Jones and [Chris] Smalling," Ferguson said at his pre-match news conference.
"Jones was a bad blow for us. He got an injury in training last weekend and he'll be out for eight to 10 weeks."
"We will try this morning with Sergio," Mancini said on Friday. "And after we try we will decide. He is getting better."
Owen, a free agent who joined after the transfer window closed, could even link up again with another of England's discarded strikers in the form of Peter Crouch.
"There's no doubt that I've played with Peter a number of times and we've done pretty well together, that's there for all to see," Owen said this week.
"It would be pretty disrespectful, though, for me to come in and say 'I'm looking forward to playing with Peter Crouch'. There are a lot of good players here, and it's certainly not in my contract that I'll be starting every game."
Terry injured his ankle playing for England in Moldova and missed Tuesday's draw with Ukraine, while Cole missed both England games.
It is the first meeting between the sides since Terry was cleared of racially abusing QPR's Anton Ferdinand in July and the clubs are still discussing whether the pre-match handshake formalities will go ahead as normal after they were abandoned in the previous two meetings between the clubs.
"He is 50/50 at the moment," Wenger told Arsenal's website. "It is a small muscular problem that is very minor. But of course we are in a situation that, because we play so many games now, should we take a gamble with him or not?"
"We are playing on Saturday, Tuesday, then go to Man City."
