Estudiantes were 3-0 winners at Barcelona but Botafogo's victory saw Juan Sebastian Veron's men eliminated.
Felipe Melo de Carvalho Tensions boiled over between Penarol and Palmeiras and both sets of fans in Montevideo.
River Plate continued their good start to the Copa Libertadores, but Fred stole the show for Atletico Mineiro.
Independiente del Valle and Rosario Central confirmed their spots in the next round of the Copa Libertadores.
A draw was enough for Nacional to move past the group stage, while Boca Juniors finally got off the mark in the Copa Libertadores.
Santa Fe won comfortably as Atletico Nacional maintained their perfect start to the Copa Libertadores.
Atletico Nacional shot three points clear at the top of Group 4 after their big win over Sporting Cristal, while Huracan saw off Penarol.
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