Locked in a tooth-and-nail battle with Real Madrid in La Liga, Barca face their bitter rivals in next weekend's 'Clasico' before immediately jetting off to the Far East.
The European champions join the December 8-18 Club World Cup at the semi-final stage along with Brazil's Santos, winners of South America's Libertadores Cup.
Japan's Kashiwa Reysol, who won their first J-League title at the weekend, take on Auckland City in the opening game of the seven-team FIFA competition on Thursday.
But Barcelona's collection of big-name players, led by Argentina's Lionel Messi, will be expected to lift the trophy - even if it turns out to be fool's gold.
Real Madrid lead Barca by three points at the top of La Liga, with a game in hand over Pep Guardiola's side heading into a potentially bruising encounter at the Bernabeu this Saturday.
"We'll need to adapt quickly," Fabregas told fifa.com. "It will be a long journey with time zone complications involved and we go into a tough game with very little time to prepare."
Barcelona, who beat Manchester United 3-1 at Wembley in May to win their fourth European Cup, face either Qatar's Al Sadd or Tunisian club Esperance on December 15 in Yokohama.
"This is Barcelona," added Fabregas. "We're obliged to win every game. It's what people expect. That makes it mandatory for us and we have to deliver."
Barring shock defeats in their respective semi-finals, Barcelona will be casting envious eyes at prolific young striker Neymar, instrumental in his side's Libertadores triumph.
"There was a lot of talk about a move to Barcelona or Real Madrid," said Xavi. "But he is staying at Santos. He will become a great player. He has amazing ability."
For the lesser-known teams, however, the Club World Cup offers a rare and lucrative chance to mix it with some of the game's best players.
"For a small amateur team like ours, it's going to take something absolutely out of the ordinary
