United, who beat Porto to reach the Champions League semis after Cristiano Ronaldo's stunning goal, face Everton in their FA Cup semi-final on Sunday while Arsenal and Chelsea square up 24 hours earlier.
With just over a month of an intriguing season remaining, all three clubs are chasing silverware on multiple fronts.
Premier League leaders United are still on course for five trophies, having already won FIFA's Club World Cup and the League Cup, while Guus Hiddink's Chelsea have not given up on the league and face Barcelona in the Champions League semis.
"We know how good Chelsea are but if we play our football we can beat any team in the world," Arsenal striker Emmanuel Adebayor said after scoring against Villarreal on Wednesday.
After being written off, manager Arsene Wenger's assertions that his Gunners young side would come good are proving accurate, even if the league is beyond them.
"These boys are winners...The focus these players have shown since the beginning of the season has been fantastic," Wenger said this week.
"The hunger they have shown every single day in training and the focus they have shown is great."
While United, Arsenal and Chelsea all have their eyes on several prizes, Everton's focus is on the FA Cup and a place in next season's Europa League. They have lost only once in their last 11 matches.
