Thursday's draw threw up a number of intriguing ties with Inter Milan, European champions in 2010, drawn against CFR Cluj of Romania and Ajax, four-times European Cup winners, taking on Steaua Bucharest who lifted the trophy in 1986.
Five-times European champions Liverpool face Zenit St Petersburg while Atletico Madrid, who won the Europa League last season, play Rubin Kazan of Russia.
Chelsea dropped down into the Europa League after becoming the first reigning European champions to fail to get through the group stage of the Champions League. Juventus and Shakhtar Donetsk qualified from the Londoners' group.
"It was destiny, it will be certainly very emotional for him," said Lyon manager Remi Garde, who used to play for Tottenham's London rivals Arsenal.
"It will not be easy. Tottenham seem to be improving by steps and I think Hugo has played a part in that because he has brought a lot of stability."
BATE Borisov v Fenerbahce
Inter Milan v CFR Cluj
Levante v Olympiakos Piraeus
Zenit St Petersburg v Liverpool
Dynamo Kiev v Girondins Bordeaux
Bayer Leverkusen v Benfica
Newcastle United v Metalist Kharkiv
VfB Stuttgart v Racing Genk
Atletico Madrid v Rubin Kazan
Ajax Amsterdam v Steaua Bucharest
Basel v Dnipro Dnipropetrovsk
Anzhi Makhachkala v Hannover 96
Sparta Prague v Chelsea
Borussia Moenchengladbach v Lazio
Tottenham Hotspur v Olympique Lyon
Napoli v Viktoria Plzen
Teams listed first will play first legs at home.
First legs to be played February 14, second legs February 21.
