Boca completed a perfect group-stage campaign with a 2-0 victory over Palestino, while Wanderers triumphed 3-0 away to Zamora to secure second position in Group Five.
Wanderers hit the front in the 34th minute in Venezuela when Matias Santos slid in to turn Joaquin Verges' cross past Zamora goalkeeper Edward Ibarbo.
Nicolas Albarracin doubled the visitors' lead in impressive fashion just after the hour-mark, controlling the ball on the edge of the area before driving it into the bottom corner, while the midfielder teed up Gaston Rodriguez in the 88th minute to complete the win.
Nilmar played a role in all three of the Brazilian visitors' goals in the first half, setting up Eduardo Sasha to make it 2-0.
Sasha teed up Nilmar's second and created Valdivia's goal two minutes before the hour-mark to complete Internacional's big win.
