Basement boys Dordrecht will finish bottom of the pile after Sunday's 3-0 defeat to Vitesse with Breda and Go Ahead Eagles looking set to occupy the relegation play-off spots.
Heracles are a place and three points above 16th-place Breda - meaning victory at the Rat Verlegh Stadion will all but seal their Eredivisie status for next season.
It would also make things decidedly gloomier for Breda, although even a loss for Robert Maaskant's side would not necessarily end their hopes.
Dennis Demmers' side are five points adrift of safety going into their final three games, with Saturday's opponents having appointed their coach for next season in midweek.
"I will strive to create an environment in which everyone reaches the maximum of themselves and each other," he told Utrecht's official website.
"You must want to improve yourself every day and push the boundaries at every level - that's the approach."
At the top, a point for Ajax at PEC Zwolle will see Frank de Boer's side tie up second place and the final UEFA Champions League spot.
