Phillip Cocu's men extended their unbeaten league run to 10 games in the process, with anything other than a home win rarely looking likely after Santiago Arias' 14th-minute opener, as the Colombian slammed in from a tight angle.
Memphis Depay doubled PSV's lead with 33 minutes on the clock, beating Mickey van der Hart with a looping header.
Depay again proved decisive 11 minutes from time, tapping in from Adam Maher's squared pass and Jurgen Locadia netted the fourth in the 90th minute after pouncing on a wayward back-pass.
Utrecht claimed an impressive 3-0 win at AZ in Saturday's late kick-off, with the visitors scoring with each of their first three shots on target in the first half.
High-flying PEC Zwolle suffered a late 2-1 loss at Cambuur, with Erik Bakker's penalty at the death earning all three points for the hosts, who in turn climb up to sixth in the table.
Rock-bottom Dordrecht picked up only their seventh point of the season as they held Groningen to a 1-1 draw at home, with Robin Gosens' 83rd-minute leveller avoiding a 13th defeat of the season.
