Fabregas and Pique came through Barca's youth academy together before heading to Arsenal and Manchester United respectively and the pair are now key members of the hugely successful Barca and Spain squads.
An avid user of Twitter to showcase his quirky sense of humour, Pique has a reputation as the clown in the dressing room.
His favourite trick is hiding his team-mates' belongings and he once caused Barcelona goalkeeper Victor Valdes to be fined by the club for arriving late at a training session because he could not find his gloves.
"It's one of the things you have to adapt to," the paper quoted him as saying. "It's not easy, it's been tough."
Fabregas has been under the microscope even more than usual at Euro 2012 since Spain coach Vicente del Bosque opted to deploy him as a roving forward in Sunday's Group C opener against Italy and started without a recognised striker.
The 25-year-old netted Spain's equaliser in a 1-1 comeback draw and it remains to be seen whether Del Bosque uses the same tactic for Thursday's match against Ireland.
"It has been a radical change in my life and like it or not it is hard to adapt," he said.
"I went from playing with complete freedom of movement to Barcelona where the game is more positional," he added.
"It was a challenge and I went through a period where I was very worried about it."
