Following a solid start to the campaign, Steve Bruce's men have won just once in their last 10 Premier League matches and sit only four points clear of the drop zone.
The solitary victory in that run was a 6-0 demolition of Fulham, but Hull have not found the net in the league since that triumph, and recent defeats to fellow strugglers Norwich City and Crystal Palace could come back to haunt them at the end of the season.
The result was Tim Sherwood's first league defeat as Spurs boss and the club's heaviest since Liverpool won 5-0 in at the Lane to seal the fate of former head coach Andre Villas-Boas.
Hull will be without first-choice goalkeeper Allan McGregor, who was sent off after a collision with Stuart O'Keefe at Palace, as Steve Harper prepares to return to the starting XI.
Jan Vertonghen, Paulinho (both ankle), Sandro (calf) and Younes Kaboul (thigh) are all nearing a return to the first team, but missed out on Wednesday's defeat to Manchester City, while Andros Townsend (hamstring) is a doubt.
