Two years after saving their Premier League skins on the final day of the season, homely Fulham are hoping to complete a remarkable journey under much-travelled manager Roy Hodgson by beating the nine-times Spanish champions.
Midfielder Simon Davies described Fulham's sensible, well-organised style as "not very exciting" at the club's training ground last week but their path to the showpiece in the German port city has been pure fantasy.
After starting in the qualifying competition against Lithuanian side FK Vetra on July 30 last year, Fulham made it out of a tough first round group containing AS Roma, CSKA Sofia and Basel, and then began toppling some of Europe's big guns in the knockout rounds.
First, holders Shakhtar Donetsk were felled, then Juventus and they followed that by beating German champions Wolfsburg before breaking SV Hamburg's hearts in the semis.
"Since staying up on the last day at Portsmouth the transformation has been film-like really," midfielder Danny Murphy, a UEFA Cup winner with Liverpool, told reporters.
"If you had written it as a book, you would laugh at the speed of it and the surrealness of it and that's all credit to Roy and the staff."
"I was suspended for the Juventus game and when they scored I felt like going home. But after that fightback we all started to believe it could a special year. We thought, we've beaten Juve, so we can beat anybody."
Ireland's Damien Duff and American Clint Dempsey have also been vital cogs as has Australian goalkeeper Mark Schwarzer who is hoping to make up for losing to Sevilla in the UEFA Cup final when playing for Middlesbrough.
"It's been a remarkable achievement to reach the final but I for one will be telling the boys that this opportunity might not come round again," Schwarzer said. "I've been lucky and this is my second and I want a positive conclusion."
Unlike Fulham, Atletico have a rich European pedigree but have not appeared in a continental final since the now defunct Cup Winners' Cup in 1986.
