Leaders Montpellier, a point above Paris Saint-Germain, are without suspended leading scorer Olivier Giroud for Saturday's trip to Dijon while playmaker Younes Belhanda could also miss out with a thigh problem.
"It's always regrettable but we will deal with it," coach Rene Girard told reporters. "We have other options, it will give an opportunity for others to express themselves."
Midfielder Mohamed Sissoko is suspended for Paris Saint-Germain's home game with Ajaccio on Sunday.
Olympique Marseille will be without winger Mathieu Valbuena for Saturday's home game with Toulouse after he suffered a knock playing for France against Germany in midweek.
"Two teams have broken away and are battling for top spot, a lot of teams are battling for third and we are part of that group," he told reporters.
"I'm satisfied with the quality produced when we play on our own pitch but sometimes we can be a bit too impatient at home," coach Rudi Garcia told reporters.
Olympique Lyon, who drew 4-4 with PSG last weekend, hope to welcome back defender Dejan Lovren from injury for Saturday's game at Nancy but Yoann Gourcuff and John Mensah will miss out, coach Remi Garde told reporters.
