Boateng scored a fifth minute goal on Saturday to set his side on the way to a 2-1 win over the United States in their second round match in Rustenburg but later limped off in the second half.
Coach Milovan Rajevac said the Germany-born midfielder would face intensive treatment in a bid to be ready for the match against Uruguay at Soccer City in Johannesburg on Friday.
"Boateng was injured against Germany already. It is going to be a huge problem to get him ready for the next game," said Rajevac following the record-equalling performance by Ghana, only the third African country to reach the last eight of the World Cup.
"We are going to see how the players react in the next days. For me the priority now will be to try and get them all ready for Friday. There is a lot of work ahead for the medical staff."
"We played in the African Nations Cup this year without eight important players and managed to reach the final. The team learnt how to compete. The most important thing at this level is to know how to compete," he said.
"Each victory counts and this is very dear. Ghana is now among the best eight teams in the world. This is fantastic," he added, keeping a stoical face at the post-match news conference but then breaking into a broad smile once it was over.
"I think we can claim to be the best team in Africa now if you consider that, plus the fact we reached the Nations Cup final," added captain John Mensah.
