Derry took over at Meadow Lane in November, but has been unable to guide his team away from the foot of the table, where County currently languish some seven points adrift of safety.
The side that County - and the remainder of the bottom four - are looking at are 20th-placed Carlisle, who visit Derry's men at the weekend.
"I tell you what, until that fat lady sings we'll be giving it a right go - an absolute right go - and it's the only way," he told the club's official website.
"They're all six pointers between now and the end of the season - every game is huge.
"I felt that at Tranmere (a 3-2 defeat for County) all game they kept going and we've got to do that again on Saturday because it's going to be an almighty battle at Meadow Lane."
Mike Jackson's Shrewsbury host inconsistent Bradford City, while Crewe travel to Gillingham and Stevenage host play-off chasing MK Dons.
Karl Robinson's MK Dons look set to make a late charge into the top six, currently six points behind Peterborough United, who host Rotherham United, with Steve Evans' side already looking assured of their play-off berth.
Russell Slade's Orient will be hoping to bounce back from defeat to promotion rivals Brentford last week when they visit Walsall, while Mark Warburton's men host Coventry City this time out.
