Leverkusen's most recent defeat by a Spanish team came at the hands of Villarreal in last season's Europa League round of 16. They had also drawn twice with Atletico Madrid earlier in the same competition.
The last time the German team beat an outfit from Spain was in 2004 when they defeated Real Madrid in the group stages.
"Last year we showed what we are capable of by finishing second in the Bundesliga - why shouldn't the current team succeed as well?" said the Leverkusen midfielder.
"In recent years they have always played in the Champions League," said Ballack. "They are simply much more steady and more stable than Leverkusen but our goal is to reach second spot in the group."
"We are playing at home so the three points are obligatory and if we then draw at Valencia that would be perfect," said Leverkusen defender Gonzalo Castro.
They conceded a stoppage-time penalty in a 1-1 draw at Real Mallorca on Saturday and coach Unai Emery was unhappy with his side's inability to convert possession into goals.
"We are going there to win. It's a very important game for us," he said.
"We are in a slightly difficult situation but we have a lot of quality on the goal-scoring front."
