Girondins Bordeaux, beaten at home by Caen last weekend, were hammered 5-1 at FC Lorient to leave coach Jean Tigana fretting over his future given the 2009 champions's mid-table malaise in 12th spot.
Kevin Gameiro grabbed a hat-trick for the team in orange while Bordeaux goalkeeper Cedric Carrasso was sent off late on after being booked twice for handling outside the area.
"It's the first time this season we've won three in a row," Marseille coach Didier Deschamps told reporters. "With our determination and application, it was the right result."
Lucho Gonzalez broke the deadlock for the frustrated champions on 68 minutes when he slotted in Gignac's pull back and Remy netted the second 10 minutes later from close range.
France striker Gignac, who scored twice in last weekend's 2-1 win at Sochaux, hobbled off on 74 minutes with a strained adductor muscle and Marseille said in a statement he would miss Wednesday's last-16 first leg at home to United.
Monaco's hopes of a revival after last Saturday's win over Lorient proved shortlived as they lost 2-0 at Stade Brest to remain third from bottom and in the relegation zone.
