Sergio Aguero, Gonzalo Higuain, Lionel Messi and Angel di Maria all scored in the victory as the home side scored three goals in a devastating 11 minute period in the first half that settled the outcome.
Messi, replicating his Barcelona form more and more with each match for his country, was brilliant and may well have finally won over the crowd at the Monumental in Buenos Aires.
"We have to be a solid team, structured in defence and accompany Lionel so he can express himself to the full," coach Alejandro Sabella told the post-match news conference.
Copa America holders Uruguay failed to end their Venezuela jinx, going a fifth World Cup qualifier in succession without beating the region's former whipping boys.
"Rondon hits it and it hits me," Godin told reporters who asked him whether he thought it was an own goal, as initially given by the South American Football Confederation.
"None of us are pleased with what we showed," Uruguay coach Oscar Tabarez told reporters speaking for the players and his staff.
Borghi's side notched up a third win as Chile made it three successive qualifying victories in the thin air of La Paz, absorbing pressure and hitting Bolivia on the break.
Forward Charles Aranguiz put Chile ahead in first-half added time and Bolivia's hopes took a further dive when defender Luis Gutierrez was sent off early in the second half for a foul on Alexis Sanchez.
Bolivia's coach Gustavo Quinteros, a member of the country's last team to go to the finals in 1994, was also sent to the stands for protesting.
