The game in London starts at 12:30pm local time and both sets of fans will have to set off very early from the north-west city or stay Friday night in the capital to make the match.
"I feel for the supporters. Of course, we will get a full house at Wembley but it's a difficult time for supporters," Moyes was quoted as saying by the Daily Telegraph on Friday.
"You are making it as really awkward as you can to get there. To get to London for 12:30 on a Saturday isn't an easy thing, without maybe going and staying overnight or getting away really early in the morning. That has been a little bit unfair on both clubs from up here."
Still paying the bill for the rebuilt Wembley, the FA has been forced to again play the semi-finals at the 90,000-seater London venue when an Everton v Liverpool clash at Manchester United's nearby Old Trafford would have suited fans better.
Television contracts dictating kick-off times and Liverpool's wish not to play on Sunday, the anniversary of the Hillsborough disaster, have tied the FA's hands it says.
Horse racing's Grand National also takes place in Liverpool on Saturday further complicating travel plans.
Moyes, in charge since March 2002, is among the bookmakers' favourites to one day succeed Sir Alex Ferguson at Manchester United given he continually leads Everton to top-half finishes in the Premier League despite limited resources.
"We have to watch that we are not making football too awkward for the supporter who has to go to his job," Moyes said.
