Rodrigo Lopez starred for Pedro Sarabia's Libertad, netting four times in his side's 4-2 win at Guarani on Sunday.
The league leaders have been impressive with nine wins from 12 matches in the Apertura campaign to be well clear at the top.
But Lopez restored Libertad's lead midway through the first half, on hand to tap in a cross at the back post.
Lopez's positioning also helped him complete his hat-trick in the 50th minute as he tapped in from close range.
On Saturday, Nacional Asuncion – who have a game in hand on their nearest rivals – took a 62nd-minute lead thanks to Fabian Balbuena, but Rodrigo Teixeira levelled for the hosts.
Christian Ovelar's brace saw Sol de America to back-to-back wins as they beat Rubio Nu 2-0, while Deportivo Capiata and 3 de Febrero drew 2-2.
