Leaders Girondins Bordeaux will miss captain Alou Diarra when they visit Le Mans on Sunday.
The 28-year-old midfielder has not fully recovered from a thigh injury.
Olympique Marseille, six points off the pace, should be at full strength for their game at arch-rivals Paris Saint-Germain on Sunday.
Coach Didier Deschamps fielded a reshuffled team which easily qualified for the Europa League round of 16 with a 3-1 home win against Copenhagen on Thursday.
"It has been a pleasant night. We qualified by scoring three goals, I managed to rest key players and we ended the game without any injured player," Deschamps told reporters.
Paris Saint-Germain, who struggle in the middle of the table, will be without Stephane Sessegnon against Marseille. The Benin playmaker will serve the last of his three suspension games.
Promising centre-back Mamadou Sakho is also suspended and fellow defender Sylvain Armand could make his return to the starting lineup after having being left on the bench for the last three games.
Captain Claude Makelele should be available even though he has not trained for three days because of a sore muscle at the beginning of the week.
Montpellier midfielder Joris Marveaux should face his younger brother Sylvain when the promoted side, currently second three points behind Bordeaux, host Stade Rennes on Saturday.
They played against each other last October when Stade Rennes thrashed Montpellier 3-0 at home after a Sylvain Marveaux opener.
Lille's Ivory Coast forward Gervinho will be out for up to six weeks with a sprained left knee.
The Northern side, who are third and host Auxerre on Sunday, already miss fellow forward Tulio De Melo, who also suffered a knee injury last week.
Auxerre will miss Poland striker Ireneusz Jelen for their game at Lille. The club's top scorer suffers from a throbbing sore back.
Olympique Lyon winger Cesar Delgado will be rested when the former champions welcome Nice on Saturday. The Argentine player has just recovered from a thigh injury.
Monaco will welcome back defender Sebastien Puygrenier and midfielder Alejandro Alonso for their game at home against Boulogne-sur-Mer on Saturday. Those two players were suspended last weekend.
