Cole, who ruptured a knee ligament at Southend in January, will be keen to impress Fabio Capello. The England manager has been selecting Steven Gerrard on the left-hand side of midfield.
Spurs manager Harry Redknapp has to choose between fit again Heurelho Gomes or former Chelsea player Carlo Cudicini for the goalkeeping spot.
Manchester United's only injury concern, Rio Ferdinand (groin) will undergo a fitness test on Friday ahead of Sunday's derby at home to rivals Manchester City.
"He has to do some positive work in training today (Friday) if he's going to make the game on Sunday. We hope he's there because you want all your big players available," manager Alex Ferguson told the club website.
City striker Emmanuel Adebayor begins a three-match suspension, while former United forward Carlos Tevez is likely to miss out with a knee injury.
Arsenal's Vito Mannone will deputise for injured goalkeeper Manuel Almunia for Saturday's visit of Wigan Athletic, while striker Robin van Persie could return from a knee problem.
Russian Andrei Arshavin has a "10 percent chance" of playing, manager Arsene Wenger told the club website, but midfielder Denilson (back) is ruled out.
Bolton Wanderers defender Joey O'Brien will be out for a minimum of four months after more knee surgery but manager Gary Megson has no fresh injury concerns ahead of Saturday's match at home to Stoke City.
Stoke goalkeeper Thomas Sorensen and striker James Beattie could both be fit after recovering from injuries picked up in last weekend's 2-1 defeat to Chelsea.
Sunderland manager Steve Bruce has a host of defenders to choose from for Saturday's visit to Burnley after George McCartney and Phil Bardsley both returned to fitness.
"The best type of headache a manager can have - injured players returning and knocking on the door to get into a winning team," Bruce told the club website.
Midfielder Lee Cattermole is a doubt, however, after missing training this week with a heel injury.
Hull City midfielder Dean Marney is fit for Saturday's visit of Birmingham City but injured defenders Anthony Gardner and Steven Mouyokolo will miss out.
City's Ecuadorian striker Christian Benitez is set to make his first start for the club, but James McFadden (thigh) and Franck Queudrue (hamstring) will be unavailable "for the foreseeable future" the club website said.
Everton will have new signing Lucas Neill available for Sunday's match at home to Blackburn Rovers after the Australian defender completed his free transfer on Thursday.
