Seventh-placed Paris St Germain face the prospect of travelling to Toulouse for Sunday's fixture without their top three strikers after Peguy Luyindula (pictured) picked up a knee injury during training on Thursday.
"We still have time to evaluate whether he will be able to play or not," coach Antoine Kombouare told reporters.
Turkey forward Mevlut Erding and Guillaume Hoarau are also doubtful for the match against 15th-placed Toulouse as they struggle to shake off respective shoulder and groin injuries.
Former Barcelona winger Ludovic Giuly could be asked to start as a lone striker in their absence.
Toulouse striker Andre-Pierre Gignac, scorer of three goals in France's last two World Cup qualifiers, is also facing a race against time to be fit for the match.
Gignac picked up a back injury after scoring France's third goal in a 3-1 defeat of Austria on Wednesday.
Leaders Olympique Lyon may be without centre back Cris against Sochaux on Saturday after the Brazilian skipped training on Thursday.
"Cris has been suffering from a groin problem for a week," coach Claude Puel told reporters.
Girondins Bordeaux coach Laurent Blanc has slammed the Ligue 1 schedule, complaining that it was unfair on the champions.
Bordeaux entertain Bayern Munich in a Champions League game on Wednesday before taking on Boulogne in domestic action next Saturday.
"Once again, Bordeaux have been treated badly," Blanc said.
"Among the three teams in the Champions League, it will be the second time that we will play less than 72 hours after a Champions League match. I'm sorry, but Marseille and Lyon do not get the same treatment."
Olympique Marseille go to Zurich on Wednesday but will play Paris St Germain next Sunday, while Lyon play their subsequent matches on Tuesday and Saturday.
Monaco striker Eidur Gudjohnsen will be out of action for three weeks after picking up a shoulder injury, the club said.
The former Barcelona forward, who will miss Sunday's game against RC Lens, has yet to score this season with the side from the principality.
Lille midfielder Yohan Cabaye has threatened to leave the club if he is not awarded more time on the pitch.
"If I only play once every three games or matches where nothing is at stake, I will have to leave," he told sports daily L'Equipe on Friday.
Cabaye, who has been left out of the starting lineup in the last three games, could start against Stade Rennes on Saturday since Florent Balmont and Rio Mavuba will be suspended
