Sao Paulo must beat ninth-placed Goias away and need their three closest rivals, including second-placed Flamengo who visit Corinthians, to slip up in order to win another title.
Sao Paulo have 62 points, Flamengo 61, with Internacional and Palmeiras both on 59.
The clash between Brazil's two most popular clubs, Flamengo and Corinthians, brings Brazilian strikers Adriano and Ronaldo face to face.
"I wouldn't want to be in his place," Adriano, also a Flamengo fan, told reporters on Thursday.
"Ronaldo always said he is a Flamengo (fan) and he went to play for Corinthians because he thought that was the best for him. It's tough to play against your club."
Despite their chances of winning the title early, caution has been the word at Sao Paulo in the build-up to the season's penultimate weekend.
"I think the chances are small, our direct rivals are not going to go cheaply. This race will go to the wire," said Ricardo, who carved out a coaching career in France and is seeking recognition of his coaching talents in his own country.
