Second-placed Real have won every game in front of their own fans, conceding only eight times and racking up an intimidating 41 goals. Sevilla have only scored 36 in 24 games all season.
But the King's Cup finalists are one of only three teams to have beaten Real this season, along with Barcelona and Athletic Bilbao, having won 2-1 at the Sanchez Pizjuan back in October.
Renato, who has a knack of scoring against Real, netted the winner that day and is confident his side can complete a double over their illustrious opponents.
"We have to get everyone in the frame of mind that Real are dangerous, but that we also have to attack them," Renato told the club's website.
"We have players who are very quick on the counter-attack. We have to make Real suffer and show what we are capable of doing."
Flying wingers Jesus Navas, Diego Perotti, and Diego Capel carry Sevilla's threat down the flanks, and it looks likely former Real Madrid striker Alvaro Negredo will lead the line.
Brazil's Luis Fabiano has been suffering with a chest injury while Mali's Frederic Kanoute has struggled of late.
DEVASTATING FORM
Sevilla lie fourth in La Liga on 43 points, three behind third-placed Valencia, but they are well off the pace in the title race with Real a distant 16 points ahead of them.
Manuel Pellegrini's team have crushed recent rivals in the league with Cristiano Ronaldo and Gonzalo Higuain in devastating form.
They are two points behind leaders Barcelona but will have one eye on next week's Champions League visit of Olympique Lyon, when they need to overturn a 1-0 first leg defeat.
Barca could have opened up a five-point lead by the time Sevilla take to the Bernabeu, with Pep Guardiola's team visiting improving Almeria.
The south-coast club are climbing away from the relegation places under new coach Juan Manuel Lillo and are unbeaten in five league games.
Barca have laboured to recent wins and will be without suspended defender Gerard Pique, with Seydou Keita and Eric Abidal out injured.
Valencia are hit hard by suspensions to first-team regulars with goalkeeper Cesar Sanchez, defenders Carlos Marchena and Miguel and midfielder Ever Banega all missing for the visit of Racing Santander on Monday.
