Silva came through 23 minutes of City's 2-0 UEFA Champions League victory at Roma on Wednesday, which saw the Etihad Stadium outfit qualify for the knockout stages.
Captain Kompany, meanwhile, has been absent for two matches with a hamstring injury, but manager Manuel Pellegrini is hopeful that both could be fit enough to start this weekend.
"We will see tomorrow," he said on Friday. "[Silva] didn't feel any pain in the knee from the 30 minutes [in Rome], so I think he will be fit.
"Kompany is in the squad list, so I don't think he will have any problem to play."
"Sergio is a very important player, but I don’' think this team depends just on Aguero," he added.
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