One of Portugal's 'Big Three' - alongside neighbours Benfica and the domineering Porto - Sporting have been disappointing in recent years, failing to lift the title since 2002 and missing out by a mile in the last two seasons, when they finished 28 and 36 points adrift of the champions.
A new club president arrived earlier this year and hired 42-year-old Domingos, who had guided unfancied Braga to second place in the domestic league and the Europa League final.
The young coach made wholesale changes to Sporting's ageing squad but his team made a slow start with two draws and a defeat in their first three league games.
"I now see a young, ambitious team in front of me and that's something that has helped me wake up happier in the morning," Domingos has told reporters.
"If we win, we will become the main candidate for the title this season," Eduardo Barroso, president of Sporting's General Assembly told Portuguese Radio Renascenca.
But Benfica will give Domingos's side their sternest test yet.
Jorge Jesus's team have also regrouped after a poor season and come into the derby after a memorable 2-2 draw at Manchester United on Tuesday that earned them a berth in the knockout phase of the Champions' League.
"I'm getting to know these players better and better and feel that the group is increasingly knit together and happy," said Domingos.
Dutch striker Ricky van Wolfswinkel, nicknamed 'Iceman' for his coolness in front of goal, arrived from Utrecht in the close-season and is Sporting's top scorer with 11 goals.
His compatriot Stijn Schaars - an international bought from AZ Alkmaar - has acted as the playmaker, gelling well with Brazil's Elias and combative Argentine Rinaudo, while speedy Spaniard Diego Capel has impressed on the wings.
