United come into the game fourth in the table, having won three consecutive league games.
Stoke, meanwhile, have suffered back-to-back defeats to Burnley and Liverpool, and have lost all six of their previous Premier League visits to Old Trafford.
"Winning, for a top club like Manchester United, is the most important thing in a week, or in a day," he said.
"Especially when we are in fourth position in the league table you have to win, otherwise others shall overcome you. Of course I had hoped that we would win on Saturday [against Hull City] but we have to win also against Stoke City.
"But in the Premier League nothing is easy. When you see Liverpool struggling against Stoke City - [scoring in the] 85th minute - that shows.
"You see Arsenal struggling against West Bromwich Albion - they could also have lost.
"Every game is difficult. That is why the Premier League is exciting, because you never know. There is an atmosphere in the stadiums [that is] fantastic and the fans are always supporting their club until the end.
"That is fantastic. That is why I want to work in the Premier League, because of that, the atmosphere."
"He was not fit to play 90 minutes [against Hull], but for 20 minutes okay," he said.
"I can use him because now he has trained for a full week with the first team. He needs match rhythm."
