Their squad is so stuffed full of talent that anything but a comfortable win for the European champions will be considered something of a shock when the last two teams in the tournament finally get their campaigns underway.
Having broken their major tournament hoodoo at Euro 2008, Spain's consistent defence, startlingly talented midfield and corps of lethal strikers have made them the favourite of many to carry off football's biggest prize in South Africa.
Andres Iniesta looks likely to win his race to recover from a thigh strain and take his place in that midfield but with quality like Cesc Fabregas or Villa's Valencia team mate Juan Mata on standby, Del Bosque may not be unduly worried.
The Swiss will also be missing midfielder Valon Behrami because of a thigh injury while Frei's ankle injury means Eren Derdiyok will partner Blaise Nkufo up front if coach Ottmar Hitzfeld sticks with his favoured 4-4-2 formation.
"They are a very compact team. At the last World Cup they went home without a win but they had a very good qualifying campaign this time," Del Bosque told Spanish television.
"They have been playing together for many years and in my opinion have many qualities."
