Wigan Athletic Wigan Athletic, Blackburn Rovers and Wolves were among the Championship sides to exit the League Cup on a night of first-round shocks.
Rochdale League Two leaders Rochdale will need to be at their best when in-form York City visit on Saturday looking to regain a play-off spot.
Tranmere Rovers Tranmere Rovers and York City will hope that the appointment of new managers will prompt a revival in their League Two fortunes on Saturday.
Bristol Rovers Wycombe Wanderers and Bristol Rovers meet in a crucial League Two clash that could have a huge bearing on the clubs' Football League status.
Hartlepool United Hartlepool United can climb off the foot of League Two for the first time in over five months when Cambridge United visit.
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