"Emmanuel Adebayor is rested. He has a little hamstring problem and we don't want to risk him," Wenger told reporters on Monday.
"Van Persie has a little groin problem," added Wenger after the Dutchman picked up the injury during Arsenal's 2-1 defeat by Chelsea in their FA Cup semi-final at Wembley on Saturday.
The good news for Arsenal was that right back Bacary Sagna is fit to return to the squad though he remains a doubtful starter at Anfield where Liverpool will bid to keep up with leaders Manchester United.
United are one point ahead of Liverpool with a game in hand and fourth-placed Arsenal are 10 points off the top.
Wenger feels, however, that his young side have the quality and the form to close the gap on the leading trio including Chelsea, who are four points behind United, after going 18 league matches unbeaten.
"We have many big games coming up and we feel we can win them," the Frenchman said.
"Winning is what we live for. We cannot be happy with only trying to remain fourth," added Wenger, whose team face United in the Champions League semi-finals.
"We want to get closer to the top and have a good opportunity to come back to six points on Liverpool.
"Third place is important, second place is important and why not first?.. You do not want to have regrets. We want to win every single game, no matter what competition we play in.
"Of course, we are disappointed having lost in the semi-finals of the FA Cup, but we want to bounce back quickly. We have so many important targets in front of us and want to focus on that."
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