The La Liga leaders take on Spartak still smarting form a shock 2-1 defeat at Celtic last time round, and have flown to Russia with all their big guns to make sure of a point that would assure their passage into the last 16.
"The artificial pitch and the cold will not be a problem or an excuse," Barca's Spain midfielder Cesc Fabregas told a news conference on Monday.
"Teams in the Champions League are always dangerous, and in Russia it is always tough. It will be a difficult match but we aren't thinking we'll qualify if we get a point. We want to win.
"We always play the same way and we will have to adapt to whatever they throw at us."
"Russian teams are now spending a lot of money and recruiting good players from around the world, and they have done a lot of good work on youth development, " Barca coach Tito Vilanova said.
"They have good players and coaches and the weather is different too. However, for now the weather conditions are good and we have played in cold conditions recently.
"If you want to win the Champions League you have to be able to beat anyone."
Spartak's Spanish boss Unai Emery is well known to Barca from his work with Almeria and Valencia in La Liga over the last few years.
"We know Emery very well and he has always caused us problems," Vilanova added. "His teams are always very organised in attack and defence. There could be some surprises."
