Malouda struck his seventh league goal of the season and Kalou came off the bench to seal victory after the break for Carlo Ancelotti's side whose early-season torrent of goals has slowed to a trickle in recent weeks.
Tottenham Hotspur rose to third, seven points behind Chelsea, after Dutchman Rafael van der Vaart made it five goals in seven since joining the north London club.
Sunderland edged Aston Villa 1-0 and Wigan Athletic's home match against Bolton Wanderers ended 1-1. West Ham United stayed bottom after a 2-1 home defeat by Newcastle United.
"It was a tough game because we didn't play so well," Ancelotti told reporters. "We suffered from some dangerous situations in the first half and in the second half we conceded too many shots from distance.
"We could have closed the game before the second goal, we had a lot of chances, but we didn't play as well as we usually do."
Chelsea have not conceded a league goal at home since March but Wolves came close to breaching the Blue wall on several occasions, most notably when Stephen Hunt's header was cleared off the line by Michael Essien.
"Bosingwa was one of the best players on the pitch," said the coach. "He put a lot of pressure on in the second half by pushing up without the ball and he had opportunities to score.
"He played very well and he is an important player for us in the future."
"This is beyond my expectations," Di Matteo said after his side came from behind to
