Phillip Cocu's PSV visit bottom side Dordrecht on Saturday, and they will be expected to claim a comfortable win.
PSV are a point clear at the top despite their five-match winning league run been ended by Groningen.
But Dordrecht, nine points from safety, are on a nine-match losing run – including conceding 14 without scoring in their past four.
PSV, the league's top goalscorers with 34, have been able to spread the load, with Memphis Depay (seven), Adam Maher (six) and Luuk de Jong (five) all contributing in the attacking third.
Frank de Boer's men were surprisingly held to a 1-1 draw at ADO Den Haag last time out to see their run of four straight wins in the league ended, but have been boosted by some good news in the lead-up to their next outing.
"If Jasper continues to grow this way, he will remain a stable factor for Ajax and for the Dutch national team," De Boer said.
"He's a real winner, with a fantastic mentality. Cillessen already is at a high level, but he can still improve in every area.
"It certainly doesn't surprise me that he's developed this way up until now."
Fred Rutten's men have conceded just seven league goals this season, carrying that record into Saturday's trip to Excelsior.
Elsewhere, fourth-placed Twente visit out-of-form Vitesse – who are winless in five league matches.
