Tony Pulis has galvanised Palace by masterminding victories over West Ham and Cardiff City to raise hopes that they can avoid relegation.
Chelsea beat Steaua Bucharest on Wednesday night to seal top spot in UEFA Champions League Group E and now turn their attention to the Premier League.
Jose Mourinho's side suffered a surprise 3-2 defeat at Stoke City last weekend, missing an opportunity to move into second place and cut the gap to leaders Arsenal to only two points.
He said: "The only target was to not win the Europa League again and that target is done,
"Now we have to do the best we can in the Champions League. In the Premier League I think the first target is to ensure we finish in the top four."
Goalkeeper Petr Cech will return to Chelsea's starting line-up after Mark Schwarzer was handed his Champions League debut in midweek.
Ramires, Andre Schurrle, Juan Mata, Gary Cahill and Fernando Torres will also be hoping for a recall, with midfielder Marco Van Ginkel (knee) Chelsea's only absentee.
None of the teams in the bottom six have more than Palace's four wins, but they must improve their away record having lost six of seven games on their travels.
