The match, one of 22 Euro 2012 qualifiers being played, is likely to bear little relation to Real's 7-3 win over Eintracht Frankfurt in 1960 which is regarded as one of the greatest exhibitions of attacking football.
In total contrast, when Scotland play the world and European champions in their Group I qualifier, coach Craig Levein could try and beat them playing a 4-6-0 formation without any recognised strikers or forwards. Real had five in 1960.
Levein used his forward-less formation in Friday's qualifier against the Czech Republic in Prague where Scotland were beaten 1-0.
His assistant Peter Houston defended the tactic as a "great strategy" which could be used again in the future.
The formation has been widely criticised by the Scottish media, but Houston told reporters: "You have a duty to try and get something points-wise for the country. I agreed with Craig, I felt it was the right way to go about it, to hit them on the counter-attack.
"I thought it was a great strategy to come up with. I thought we could counter-attack against them. I think Scotland as a nation are better at counter-attacking."
Asked if Levein would use the same tactic in the future, Houston replied: "If it is the right thing to do.
"It doesn't mean that we go into the game against Spain with the same formation. Every game has a different outlook. Spain have different players from the Czech Republic, we will look forward to it."
