The 22-year-old German has been in a coma since his car collided with a truck last Friday. Hospital doctors say his condition remains critical although he has shown signs of stabilising.
Hoffenheim won their previous two matches before the accident and drew 0-0 against Augsburg last week in a game overshadowed by the previous day's car crash.
"We are sucking up every and any positive signal and we strengthen our hope," team manager Andreas Mueller told reporters.
Coach Markus Babbel, a former Bayern player, added: "Obviously the players feel the need to care for Boris and visit him but it makes no sense at the moment to go there as he needs absolute quiet".
The Bavarians have yet to drop a point at home against Saturday's opponents and last season's 7-1 demolition represented the heaviest Bundesliga defeat for Hoffenheim.
"It is important to show an instant reaction against Hoffenheim, to step on the gas so that our Bundesliga rivals see that Bayern may have lost but they have not been hurt by it," said chief executive Karl-Heinz Rummenigge.
"Sammer's comments were not unjustified, I think one should accept them. He is the coach's equal partner and he is absolutely entitled to do this," said Hoeness.
