Barca were eliminated from Europe's premier club competition by title rivals and league leaders Atletico Madrid on Wednesday, succumbing to a 2-1 aggregate defeat to Diego Simeone's men after losing the second leg 1-0.
That defeat ended the Catalan club's hopes of a quadruple, and Gerardo Martino's men will now need to refocus their efforts on retaining the league crown they won in dominant fashion last term.
Martino's men are one point behind Atletico and two ahead of fierce rivals Real Madrid with six games remaining in an enthralling title race that promises to go to the wire.
Any slip up could be extremely damaging to Barca's hopes of a 23rd Spanish title, especially with Atletico and Real facing strugglers Getafe and Almeria respectively.
Barca cruised to a 4-0 victory in the reverse fixture at Camp Nou in November but Granada defender Dimitri Foulquier insists Lucas Alcaraz's men have nothing to fear.
"They're (Barcelona) a team with very good players, but they're still just men and we shouldn't fear anyone," Foulquier said.
"What they did yesterday (Wednesday in the Champions League), doesn't matter to us.
"All we're focused on is the match on Saturday and we'll have to give everything we've got, to get a draw or a win."
Alcaraz's side are just three points above the relegation zone in 15th following a 4-1 humbling at the hands of Malaga, and could be dragged further into the mire if results go against them this weekend.
And with next Wednesday's Copa del Rey final with Real on the horizon, it would come as no surprise if Martino opted to shuffle his pack ahead of that crucial third Clasico of the campaign.
