Lens, who sit second bottom, are nine points adrift of safety while champions PSG are just a point behind leaders Lyon.
The visitors will be fresher after PSG were played on Wednesday in the Coupe de France.
But Laurent Blanc's men lifted morale after a goalless Ligue 1 draw against Monaco on Saturday by beating the same opponents 2-0 at the Parc des Princes.
Goals from David Luiz and Edinson Cavani were enough to send PSG through to the competition's semi-finals, keeping alive ambitious hopes of a quadruple trophy haul this term.
"I think we played two very good games against Monaco," the Brazil defender told the club's official website.
"The difference was that we scored early [on Wednesday].
"We are playing well and we are getting close to the key moment of the season.
"Now is the time to start winning titles together."
Also in PSG's favour is their recent record against Lens, which sees them unbeaten in 10.
Since Lens' 3-1 triumph in Paris in November 2006, PSG have won six of 10 meetings in all competitions.
Cavani was infamously dismissed for his 'sniper' celebration following a 55th-minute penalty in the match.
