With leaders Paris Saint-Germain already crowned league champions and Olympique Marseille certain to finish second, the race for the third and final Champions League spot is on with two games to play.
Lyon, who missed out on the competition for the first time in 12 years this season, occupy the coveted berth with 63 points, three ahead of fourth-placed Lille, who visit Montpellier, and Nice in fifth. Saint-Etienne are sixth with 59.
"We will be happy if we take all three points but if we only manage a draw, we're not going to complain," Lyon's Gueida Fofana told reporters.
"We know that we can widen the gap with Nice but the league won't be over," the midfielder added.
"It will be a highly charged game," said Fofana, who has played in the right-back position in the past few weeks as France's Anthony Reveillere has been dropped from the squad.
"It was a perfect weekend," forward Ronny Rodelin told the club's website.
"It has brought us back in contention. We know that we can beat every team. The squad still believe we can clinch [the third spot]. We have to win our games, then see what the others do."
Saint-Etienne, who have already qualified for next season's Europa League preliminary round thanks to their League Cup victory last month, host Marseille.
PSG, who clinched the title with victory at Lyon last weekend, host Stade Brest and hope to have a calm day after violence marred Monday's title celebrations in Paris.
"We'll celebrate. We have worked very hard for two years to win this title, it's normal to celebrate despite what happened. Fans expect to party, so do the players," chairman Nasser al-Khelaifi told daily Le Parisien.
