Udinese, like Malaga hit by a flurry of summer departures, held Braga 1-1 away and Belarus champions BATE Borisov appear on the brink of a second successive group stage appearance after a 2-0 home win over Israel's Hapoel Kiryat Shmona.
AEL Limassol, hoping to provide more success for Cyprus after APOEL's run to the quarter-finals last season, won 2-1 against Anderlecht who, like Tottenham Hotspur, are suffering the consequences of Chelsea winning the trophy last season.
Tottenham missed out altogether because Chelsea, who finished outside the top four in the English Premier League, took their place under UEFA's complex qualification system. Anderlecht, who should have gone straight into the group stage, were pushed back into the third qualification round.
Udinese, beaten at the same stage by Arsenal last season, went ahead in the 23rd minute against the run of play with a Dusan Basta header before Braga's Brazilian left-back Ismaily rifled in a stunning equaliser from long range in the 68th minute.
Defeat for Udinese against the Portuguese side would leave Italy with only two teams in the group stage after Serie A dropped below the Bundesliga in UEFA's coefficients system.
Anderlecht, who beat Lithuania's Ekranas 11-0 on aggregate in the previous round, found AEL a different proposition and they fell behind to a Dosa Junior goal in the 34th minute.
Milan Badelj scored in the 74th minute to give Croatian champions Dinamo Zagreb a 2-1 win at home to Maribor, from neighbouring Slovenia, in the night's other tie.
