Juan Mata has been rewarded for his fine form for Manchester United with a recall to the Spain squad.
Mata was on Thursday named United's player of the month for October, narrowly edging out Ander Herrera, who was also included by Spain boss Julen Lopetegui for the World Cup qualifier with Macedonia and friendly against England at Wembley.
Sergio Escudero has earned his first senior call-up after impressing for Jorge Sampaoli's Sevilla, while Borussia Dortmund's Marc Bartra is included in the absence of injured trio Gerard Pique, Sergio Ramos and Javi Martinez.
"We have a lot of absences and we can't stop to mourn them," said Lopetegui, whose side meet Macedonia on November 12 and England three days later. "They are what they are and we can't change them.
"Some of the players are certainties but we have questions about how they will compete. The second game is a friendly and it allows us to make other decisions, especially if we need to cover any possible casualties."
"There is no problem if a player is of one age or another," he said. "Villa is in another league and he's at a good level. He's competitive and making a difference, but we have the three strikers.
"I will not close the door to anyone. We'll make decisions based on what we see and how we feel."
Midfielders: Ander Herrera (Manchester United), Sergio Busquets (Barcelona), Koke (Atletico Madrid), Isco (Real Madrid), Thiago (Bayern Munich), David Silva (Manchester City), Juan Mata (Manchester United), Lucas Vazquez (Real Madrid), Jose Callejon (Napoli), Vitolo (Sevilla).
Forwards: Alvaro Morata (Real Madrid), Diego Costa (Chelsea), Nolito (Manchester City), Aritz Aduriz (Athletic Bilbao).
