Previews: Next stop Fulham for United juggernaut
The sixth-round tie comes in the middle of a hectic period for Alex Ferguson's side, who beat Newcastle United 2-1 on Wednesday to retain their seven-point lead in the title race, but the thought of scooping all five competitions they entered this season will be driving them on.
As well as the League Cup, which they won on penalties against Tottenham Hotspur last weekend, United have also captured FIFA's Club World Cup and are well-placed to reach the quarter-finals of the Champions League after drawing 0-0 with Inter Milan in the San Siro.
Also on Saturday, Chelsea are away at Championship Coventry City, while on Sunday Arsenal host Championship high-flyers Burnley hoping to avenge a League Cup defeat earlier in the season by the Lancashire outfit. Everton host Middlesbrough in Sunday's other FA Cup clash.
United, a record 11-times winners of the competition, will no doubt rest some of their key players on Saturday as Ferguson juggles his squad for the clash with Inter.
That could mean another start for keeper Ben Foster and midfielder Darron Gibson, who impressed against Spurs.
Fulham defender Paul Konchesky, a finalist with West Ham United in 2006, says his side will be relishing the chance of reaching the last four.
"The mood is great," he told the club's website. "We're playing in the quarter-final of the FA Cup against one of the best teams in the world. That's the sort of game that every player wants to be involved in, it's exciting for the club."
Dutchman Guus Hiddink was just a spectator when Chelsea beat Championship side Watford 3-1 in the previous round with Ray Wilkins in temporary charge but he is looking forward to his first real taste of the competition.
"When I was abroad people were talking not just about the Premier League but also the FA Cup, so it's very important to us," Hiddink told the FA's website.