Bayern's appeal against a three-match suspension imposed on the Frenchman for a bad tackle in the semi-finals against Olympique Lyon was rejected by the Court of Arbitration for Sport (CAS).
It means Bayern will be without one of their two most creative players as they take on one of Europe's best defences but coach Louis van Gaal was prepared to shrug off the loss.
"We do not depend on (Arjen) Robben or Ribery," Van Gaal told reporters on Monday before CAS announced the decision. "You (reporters) have said we depend on them but we have said it often that we do not depend on them."
"Hamit is in very good form," Bayern midfielder Bastian Schweinsteiger told reporters.
"Individually Franck is a great player but if you saw what Hamit did in Lyon then there is no concern. Hamit is also more active in the defence," said the Germany international.
"I coach my players to play attractive football and win and he (Mourinho) coaches only to win," said van Gaal.
