Giuseppe Iachini's side are unbeaten in their last 10 clashes at Stadio Renzo Barbera, a run highlighted by a 3-1 success against Napoli last month.
So Juve, already 11 points clear of the second-placed Roma as they hunt a fourth successive title, will not be taking anything for granted on Saturday.
A rare defeat - in the first leg of their Coppa Italia semi-final to Fiorentina last week - may have been the wake-up call Massimiliano Allegri's side required.
"We need to keep our focus," Pepe told Sky Sport Italia.
"Palermo have gone a long time without losing a home game and we must try to stretch our advantage over Roma."
"I've been training for eight months and feel good," he added.
"My legs are getting back to what they were before and I'm ready, as all the others are, to make my contribution."
Juve have drawn their last three away matches in Serie A. In addition to Pogba's absence, they could be without Andrea Pirlo (calf) again.
Palermo's excellent home form sees them 10th in the table but have failed to win since upsetting Rafael Benitez's side.
Dybala has scored 12 Serie A goals this season, leaving him fifth in the scoring charts, just three strikes adrift of Inter's Mauro Icardi and Juve's Carlos Tevez.
Palermo's last success was in February 2011 in a season where they did the double over the Italian giants.
Arturo Vidal and Fernando Llorente scored the goals in Juve's 2-0 Serie A win earlier this season.
