Eusebio Di Francesco's side have moved out of the drop zone due to an impressive resurgence in the last three games, beating Atalanta and Chievo and earning a draw with Cagliari.
They face a stern test in attempting to continue their impressive form against leaders Juventus, who head into the game on the back of a disappointing result in Europe in midweek.
Roma cut Juve's lead at the summit to five points with a 2-0 success against Milan on Friday and the capital club will be hoping Sassuolo do them a favour by securing a shock triumph.
However, the prospects of Di Francesco's men consigning the champions to only their third league loss of the campaign would appear slim, especially considering the heavy defeat Conte's side inflicted on them in the reverse fixture.
But that defeat is not playing on the mind of Sassuolo captain Francesco Magnanelli, who is undaunted by the task facing Conte's men.
"That win against Chievo (last weekend) gave us life," Magnanelli told Tuttosport.
"Against Juventus we face an extremely tough match, but this town and this team deserve to be playing in these matches. We will give it a go.
"We know we have a tough run-in, but at this point we deserve to be fighting to stay up and we will try right until the end. The whole group believes."
