Seedorf has made a fine start to his coaching career at San Siro, losing just one league game since taking over from Massimiliano Allegri last month and keeping Milan in contention for UEFA Europa League qualification.
Indeed, Milan are five points behind fifth-placed city rivals Inter and making up that deficit could be crucial for a team that are 1-0 down from the first leg of their UEFA Champions League last 16 clash with Atletico Madrid.
However, Milan now host the defending champions Juve, who are in pole position to seal a third straight Serie A title having lost just one league game all season.
Roma will look to keep up the pressure on Antonio Conte's side with a win over Inter on Saturday.
But Walter Mazzarri's Inter are also in strong form with just one defeat in five and will hope that recent acquisition Hernanes, a January signing from Roma's arch-rivals Lazio, can help them secure a long-awaited win against the capital club.
Meanwhile, Napoli travel to relegation-threatened Livorno as Rafael Benitez's side aim to further cement third place.
A total of 31 points separate the two sides, but the hosts should take heart from recent performances, which have seen Livorno beat Sassuolo and Cagliari to boost their survival hopes.
Benitez's men know that any slip up will allow Fiorentina, ravaged by suspensions to Borja Valero, David Pizarro and Modibo Diakite following ugly scenes in Monday's draw with Parma, to gain ground in the race for the final Champions League place with victory over Lazio.
Catania and Cagliari will look to ease their respective relegation worries with wins against Genoa and Udinese, while Chievo can pull away from the bottom three with triumph at Atalanta and Torino host Sampdoria.
