Lyon's trip to Toulouse on Saturday has been postponed following advice from regional police.
The Prefecture de Haute-Garonne called for the Ligue 1 match to be called off in the wake of protests in Toulouse.
According to officials, 57 people, including 48 police officers, were wounded on December 1 after clashes with what they described as "violent demonstrators".
The decision comes after Paris Saint-Germain's match at home to Montpellier was also cancelled amid continued unrest in the French capital.
Three people have been killed since the demonstrations started last month, according to the latest figures, though the country has not declared a state of emergency.
Suite à la demande de la Préfecture de Haute-Garonne, la reporte la rencontre / comptant pour la 17e journée et initialement prévue ce samedi 8 décembre à 20h December 4, 2018
